Aberrant gene expression and aging: Examination of tissue-specific mRNAS in young and old rats
| Autor: | Edward L. Schneider, David B. Danner, Alice I. Sato |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Aging
Cell Biology Andrology Immunoglobulin kappa-Chains Gene expression medicine Animals Tissue specific Tissue Distribution RNA Messenger Gene Serum Albumin Messenger RNA Rats Inbred Strains Blotting Northern Molecular biology Rats medicine.anatomical_structure Gene Expression Regulation Mrna level Organ Specificity DNA methylation Autoradiography Keratins Female Atrial Natriuretic Factor Function (biology) Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 54:1-12 |
| ISSN: | 0047-6374 |
| Popis: | It has been suggested that aberrant gene expression may play a role in aging. To test this possibility, we examined the steady-state mRNA levels for five tissue-specific genes of known function in young (6 month) and old (24 month) rats. Six different tissues from three animals of each age were analyzed using a hybridization assay estimated to be able to detect one mRNA copy per cell. At this level of sensitivity, no aberrant gene expression was seen. The results indicate that these tissue-specific genes retain their fidelity of expression with age. |
| Databáze: | OpenAIRE |
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