Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants
| Autor: | Elizabeth P, Ehlinger, Emily M, Webster, Helen H, Kang, Aislyn, Cangialose, Adam C, Simmons, Kimberly H, Barbas, Sandra K, Burchett, Mary L, Gregory, Karen M, Puopolo, Karen P, Puopolo, Sallie R, Permar |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Adolescent Congenital cytomegalovirus infection Antibody Affinity Cytomegalovirus Gestational Age Infant Premature Diseases Breast milk Immunoglobulin G Leukocyte Count Young Adult Major Articles and Brief Reports fluids and secretions Immune system Immunology and Allergy Medicine Humans Infant Very Low Birth Weight Avidity Immunity Cellular biology Milk Human business.industry Infant Newborn virus diseases food and beverages Viral Load medicine.disease Infectious Disease Transmission Vertical Immunity Humoral Immunoglobulin A Low birth weight Infectious Diseases Breast Feeding Immunology Cytomegalovirus Infections biology.protein Female medicine.symptom business Breast feeding Viral load Infant Premature |
| Zdroj: | The Journal of infectious diseases. 204(11) |
| ISSN: | 1537-6613 |
| Popis: | Introduction. Transmission of cytomegalovirus (CMV) via breast milk can lead to severe acute illness in very low-birth-weight (VLBW) preterm infants. Although the majority of CMV-seropositive women shed CMV in milk, symptomatic postnatal infection of VLBW infants occurs infrequently, suggesting that virologic or immunologic factors in milk may be associated with the risk and severity of postnatal CMV infection. Methods. We investigated the magnitude of CMV-specific cellular and humoral immune responses in milk of 30 seropositive mothers of VLWB preterm infants and assessed their relationship to milk CMV load and symptomatic CMV transmission. Results. Milk immunoglobulin G (IgG) avidity was inversely correlated to milk CMV load (r = −0.47; P = .009). However, milk CMV load and CMV-specific cellular and humoral immune responses were similar in mothers of VLBW infants with and those without symptomatic postnatal CMV infection. Conclusions. Similar immunologic parameters in milk of CMV-seropositive mothers of VLBW infants with and without symptomatic postnatal CMV infection indicate that screening milk by these parameters may not predict disease risk. However, the inverse correlation between milk CMV IgG avidity and CMV load may suggest that enhancement of maternal CMV-specific IgG responses could aid in reduction of CMV shedding into breast milk. |
| Databáze: | OpenAIRE |
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