Ultrasound Simulation in the Distal Radius Using Clinical High-Resolution Peripheral-CT Images
| Autor: | Robert S. Siffert, Vincent Le Floch, Jonathan J. Kaufman, Adi Cohen, Donald J. McMahon, Elizabeth Shane, Gangming Luo |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Materials science Acoustics and Ultrasonics Bone density Osteoporosis Biophysics Article Bone Density Image Interpretation Computer-Assisted medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Ultrasonography Radiological and Ultrasound Technology business.industry Ultrasound Radius medicine.disease Peripheral Ultrasonic sensor Radiology Secondary osteoporosis Tomography X-Ray Computed business Bone mass Biomedical engineering |
| Zdroj: | Ultrasound in Medicine & Biology. 34:1317-1326 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2008.01.006 |
| Popis: | The overall objective of this research is to develop an ultrasonic method for noninvasive assessment of the distal radius. The specific objective of this study was to examine the propagation of ultrasound through the distal radius and determine the relationships between bone mass and architecture and ultrasound parameters. Twenty-six high-resolution peripheral-CT clinical images were obtained from a set of subjects that were part of a larger study on secondary osteoporosis. A single midsection binary slice from each image was selected and used in the two-dimensional (2D) simulation of an ultrasound wave propagating from the anterior to the posterior surfaces of each radius. Mass and architectural parameters associated with each radius, including total (trabecular and cortical) bone mass, trabecular volume fraction, trabecular number and trabecular thickness were computed. Ultrasound parameters, including net time delay (NTD), broadband ultrasound attenuation (BUA) and ultrasound velocity (UV) were also evaluated. Significant correlations were found between NTD and total bone mass (R2 = 0.92, p < 0.001), BUA and trabecular number (R2 = 0.78, p < 0.01) and UV and trabecular bone volume fraction (R2 = 0.82, p < 0.01). There was only weak, statistically insignificant correlation (R2 < 0.14, p = 0.21) found between trabecular thickness and any of the ultrasound parameters. The study shows that ultrasound measurements are correlated with bone mass and architecture at the distal radius and, thus, ultrasound may prove useful as a method for noninvasive assessment of osteoporosis and fracture risk. |
| Databáze: | OpenAIRE |
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