Optically pumped magnetometers disclose magnetic field components of the muscular action potential
| Autor: | Christoph Braun, Thomas Middelmann, Davide Sometti, Philip J. Broser |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Field (physics) Magnetometer Acoustics Quantitative Biology::Tissues and Organs Physics::Medical Physics Biophysics Neuroscience (miscellaneous) Magnetometry Action Potentials Signal Proof of Concept Study law.invention 03 medical and health sciences 0302 clinical medicine Optics law Humans Prospective Studies Muscle fibre Muscle Skeletal Dipole source Physics business.industry Foot 030229 sport sciences equipment and supplies Thermal conduction Action (physics) Electric Stimulation Magnetic field Dipole Magnetic Fields Neurology (clinical) Tibial Nerve business human activities Magnetic dipole 030217 neurology & neurosurgery |
| Zdroj: | Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 56 |
| ISSN: | 1873-5711 |
| Popis: | Aim Aiming at analysing the signal conduction in muscular fibres, the spatio-temporal dynamics of the magnetic field generated by the propagating muscle action potential (MAP) is studied. Method In this prospective, proof of principle study, the magnetic activity of the intrinsic foot muscle after electric stimulation of the tibial nerve was measured using optically pumped magnetometers (OPMs). A classical biophysical electric dipole model of the propagating MAP was implemented to model the source of the data. In order to account for radial currents of the muscular tubules system, a magnetic dipole oriented along the direction of the muscle was added. Results The signal profile generated by the activity of the intrinsic foot muscles was measured by four OPM devices. Three OPM sensors captured the spatio-temporal magnetic field pattern of the longitudinal intrinsic foot muscles. Changes of the activation pattern reflected the propagating muscular action potential along the muscle. A combined electric and magnetic dipole model could explain the recorded magnetic activity. Interpretation OPM devices allow for a new, non-invasive way to study MAP patterns. Since magnetic fields are less altered by the tissue surrounding the dipole source compared to electric activity, a precise analysis of the spatial characteristics and temporal dynamics of the MAP is possible. The classic electric dipole model explains major but not all aspects of the magnetic field. The field has longitudinal components generated by intrinsic structures of the muscle fibre. By understanding these magnetic components, new methods could be developed to analyse the muscular signal transduction pathway in greater detail. The approach has the potential to become a promising diagnostic tool in peripheral neurological motor impairments. |
| Databáze: | OpenAIRE |
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