Role of the vitamin K epoxide reductase complex subunit 1 (VKORC1) -1639GA gene polymorphism in patients with retinal vein occlusion
| Autor: | Iris Steinbrugger, Wilfried Renner, Anton Haas, D. F. Rabensteiner, Tobias Brockmann, Eva Maria Pöschl, Martin Weger, Yosuf El-Shabrawi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Vitamin K Genotype Vitamin K Epoxide Reductase Complex Subunit 1 Biology Polymorphism Single Nucleotide Cellular and Molecular Neuroscience Central retinal vein occlusion Risk Factors Internal medicine Vitamin K Epoxide Reductases Retinal Vein Occlusion medicine Humans Genetic Predisposition to Disease Allele frequency Aged Genetics Clotting factor Aged 80 and over Middle Aged medicine.disease Sensory Systems Ophthalmology Endocrinology Logistic Models Case-Control Studies Branch retinal vein occlusion Vitamin K epoxide reductase Female VKORC1 |
| Zdroj: | Current eye research. 38(12) |
| ISSN: | 1460-2202 |
| Popis: | Retinal vein occlusion (RVO) is a major vision-threatening disease. Vitamin K epoxide reductase recycles reduced vitamin K, which is essential for the gamma carboxylation of clotting factors II, VII, IX, X and proteins C and S. Recently, the vitamin K epoxide reductase complex subunit 1 (VKORC1) -1639GA (rs9923231) polymorphism has been reported as a novel risk factor for RVO in a Turkish population. The present study was set to confirm or to refute this association in a larger cohort of patients with RVO.The present case-control study comprised 285 patients with central RVO, 401 patients with branch RVO and 333 control subjects. Genotypes of the VKORC1 -1639GA polymorphism were determined by 5' exonuclease assay (TaqMan).No significant differences in either genotype distributions or allele frequencies of the vitamin K epoxide reductase complex subunit 1 -1639GA polymorphism were found between patients and control subjects (p 0.05). In a logistic regression analysis neither branch nor central RVO was predicted by the vitamin K epoxide reductase complex subunit 1 -1639GA genotypes, but by arterial hypertension, ever-smoking status and in case of central RVO additionally by diabetes mellitus.Our data suggest that the vitamin K epoxide reductase complex subunit 1 -1639GA gene polymorphism is unlikely a major risk factor for patients with either central or branch RVO. |
| Databáze: | OpenAIRE |
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