Human papillomavirus type 18 infection in a female renal allograft recipient: a case report
| Autor: | Olga Jermakova, Rafail Rozental, Ieva Ziedina, Svetlana Chapenko, Dace Razeberga, Alina Sultanova, Baiba Lesina-Korne, Maksims Cistjakovs, Modra Murovska |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Case Report HPV-18 Renal allograft transplantation Human Papillomavirus DNA Tests 03 medical and health sciences Postoperative Complications 0302 clinical medicine Focal segmental glomerulosclerosis Pregnancy medicine Humans RNA Messenger Human Papillomavirus DNA Test Kidney transplantation Vaginal Smears Medicine(all) Cervical cancer Human papillomavirus 18 Glomerulosclerosis Focal Segmental business.industry Papillomavirus Infections Oncogene Proteins Viral General Medicine Viral Load medicine.disease Kidney Transplantation Abortion Spontaneous DNA-Binding Proteins Transplantation Immunosuppressive therapy 030104 developmental biology 030220 oncology & carcinogenesis Immunology Prednisolone RNA Viral Female Virus Activation business Viral load Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of Medical Case Reports |
| ISSN: | 1752-1947 |
| Popis: | Background Human papillomavirus type 18 is the second most common cause of cervical cancer and is found in 7 to 20 % of cases of cervical cancer. The oncogenic potential of high-risk human papillomavirus is associated with expression of early proteins E6 and E7. Due to long-term immunosuppressive therapy, renal transplant recipients have a higher risk of developing persistent human papillomavirus infection. Case presentation A 29-year-old white woman from Latvia with chronic focal segmental glomerulosclerosis received renal allograft transplantation and was prescribed immunosuppressive therapy with cyclosporine, prednisolone, and mycophenolate mofetil. Two weeks after renal transplantation, her cervical swab was positive for human papillomavirus consensus sequences. After 6 months, quantitative polymerase chain reaction showed a high viral load of 3,630,789 copies/105 cells of high-risk human papillomavirus type 18 and expression of E6 and E7 oncogenes in her cervical swab and urine sample. One year after renal transplantation, the viral load in her cervical swab increased significantly to 7,413,102 copies/105 cells. Messenger ribonucleic acid of human papillomavirus type 18 E6 and E7 oncogenes were also detected. Shortly after this, she had an unsuccessful pregnancy which resulted in a spontaneous abortion at 6/7 weeks. Two months after the abortion her viral load sharply decreased to 39 copies/105 cells. Oncogenes E6 and E7 messenger ribonucleic acid expression was not observed in this period. Conclusions This case report represents data which show that immunosuppressive therapy may increase the risk of developing persistent high-risk human papillomavirus infection with expression of E6 and E7 oncogenes in renal transplant recipients. However, even during this therapy the immune status of a recipient can improve and contribute to human papillomavirus viral load reduction. Spontaneous abortion can be considered a possible contributory factor in human papillomavirus clearance. |
| Databáze: | OpenAIRE |
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