A droplet microfluidic platform for high-throughput photochemical reaction discovery
| Autor: | Daniel J. Steyer, Robert T. Kennedy, Alexandra C. Sun, Emory M. Payne, Anthony R. Allen, Corey R. J. Stephenson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Materials science Process development Science Microfluidics General Physics and Astronomy Alkenes 010402 general chemistry Photochemistry 01 natural sciences Methylation General Biochemistry Genetics and Molecular Biology Article Automation High-Throughput Screening Assays Photocatalysis Throughput (business) Flow chemistry Multidisciplinary 010405 organic chemistry Drug discovery Continuous flow Resource constraints Reproducibility of Results General Chemistry ESI mass spectrometry Photochemical Processes 0104 chemical sciences Indicators and Reagents |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020) |
| ISSN: | 2041-1723 |
| Popis: | The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development of a droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. This platform allows for enhanced material efficiency, as reactions can be performed on picomole scale. Furthermore, high-throughput data collection via on-line ESI mass spectrometry facilitates the rapid analysis of individual, nanoliter-sized reaction droplets at acquisition rates of 0.3 samples/s. We envision this high-throughput screening platform to expand upon the robust capabilities and impact of photochemical reactions in drug discovery and development. Translating discovery scale vial-based batch reactions to continuous flow scale-up conditions is limited by significant time and resource constraints. Here, the authors report a photochemical droplet microfluidic platform, which enables high throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. |
| Databáze: | OpenAIRE |
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