'Naïve' and 'memory' CD4+ T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion
| Autor: | Anthony Tarragona, Sabine Kinloch-de-Loes, Richard Tilling, Eva-Lotta Larsson-Sciard, Parisa Amjadi, MargaretA Johnson, Clive Loveday, George Janossy, Frances Gotch, DouglasJ.S King |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Adolescent T cell Receptors Antigen T-Cell alpha-beta Immunology CD4-CD8 Ratio Immunoglobulin Variable Region chemical and pharmacologic phenomena Viremia Biology Antigen HIV Seropositivity medicine Immunology and Allergy Humans Seroconversion Receptor Repertoire T-cell receptor hemic and immune systems medicine.disease Virology medicine.anatomical_structure Female Immunologic Memory |
| Zdroj: | Immunology letters. 66(1-3) |
| ISSN: | 0165-2478 |
| Popis: | The progression of 'naive' and 'memory' T-cells and the T-cell receptor Vbeta (TCR Vbeta) repertoire dynamics within the peripheral CD4+ T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR Vbeta repertoire perturbations were observed within the CD4+ T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6-8 months after seroconversion. The ratio of 'naive' to 'memory' CD4+ T-cells as well as the TCR Vbeta repertoire dynamics did not appear to correlate with absolute numbers of CD4 T-cells. |
| Databáze: | OpenAIRE |
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