Assessment of major salivary gland size in primary Sjögren’s syndrome: comparison between clinical examination and ultrasonography
| Autor: | Laëtitia Le Pottier, Divi Cornec, Pauline Marteau, Thierry Marhadour, Sophie Varache, Yves Gauvin, Maelenn Gouillou, Valérie Devauchelle-Pensec, Dewi Guellec, Guillermo Carvajal Alegria, Sebastian Costa, Jacques-Olivier Pers, Alain Saraux, Yves Renaudineau, Sylvie Boisramé, Sandrine Jousse-Joulin |
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| Přispěvatelé: | Centre National de Référence CERAINO, Service de Rhumatologie (Hôpital de la Cavale Blanche), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Anatomie et Pathologie, Brest, Service ORL, Department of Odontology, Laboratoire d'Immunologie et Immunothérapie [Brest] |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Intraclass correlation Concordance salivary glands [SDV]Life Sciences [q-bio] Submandibular Gland Physical examination Severity of Illness Index Palpation parotidomegaly 03 medical and health sciences 0302 clinical medicine Cohen's kappa Rheumatology stomatognathic system Major Salivary Gland medicine Humans Parotid Gland 030212 general & internal medicine Physical Examination Ultrasonography 030203 arthritis & rheumatology medicine.diagnostic_test business.industry ultrasound Ultrasound Organ Size Middle Aged Parotid gland stomatognathic diseases Sjogren's Syndrome medicine.anatomical_structure ROC Curve Sjögren’s syndrome Female business Nuclear medicine ESSDAI |
| Zdroj: | Joint Bone Spine Joint Bone Spine, Elsevier Masson, 2019, ⟨10.1016/j.jbspin.2019.01.025⟩ |
| ISSN: | 1297-319X |
| DOI: | 10.1016/j.jbspin.2019.01.025⟩ |
| Popis: | Objective Parotidomegaly is a criterion of the EULAR Primary Sjogren Syndrome Disease Activity Index (ESSDAI). The cut-off value was set at 3 cm in length for the parotid gland, 2 cm for the submandibular glands. However, clinical appreciation of salivary glands size remains hazardous. The objective is to evaluate inter-observer reproducibility of parotid gland measurement by palpation, and to secondary evaluate its reliability compared to US assessment. Methods Outpatients with primary Sjogren Syndrome (pSS) or with a diagnostic suspicion, in a single reference centre, were included. They underwent clinical examination by two independent investigators (VDP and DC), evaluating: parotid gland swelling, parotid gland size (direct measurement with a decameter under the mandibular angle), and pain. Cohen's kappa coefficient was calculated to determine inter-observer concordance for parotid gland swelling, and intraclass correlation coefficient to determine inter-observer agreement of gland size measurement. Results Thirty-four patients (33 women, 1 man) were included. Clinical data were complete for 33 patients. Inter-observer concordance Kappa coefficient was 0.90 [0.76–1.00] for detection of parotidomegaly over 66 parotid glands. It was of 0.60 [0.42–0.73] for gland length measurement. For one observer, the median cut-off for defining parotidomegaly was 4.15 cm; for the second observer, it was of 4.92 cm. For submandibular glands palpation, no correlation was found between investigators. A significant association between clinical parotidomegaly and a larger echographic surface was found. Conclusion Clinical measurement of parotidomegaly was concordant between two observers on a binary mode (presence/absence). However, concordance on direct measurement was weak. US could be a complementary examination. |
| Databáze: | OpenAIRE |
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