The role of smoking and alcohol intake in the development of high-grade squamous intraepithelial lesions among high-risk HPV-positive women
| Autor: | Susanne K. Kjaer, Edith I. Svare, Morten Grønbæk, Birthe Lykke Thomsen, Adriaan J. C. van den Brule, Chris J.L.M. Meijer, Christian Munk, Janne Schurmann Tolstrup |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Human Papillomavirus Positive Oncology medicine.medical_specialty Alcohol Drinking Uterine Cervical Neoplasms Cervix Uteri Cervical intraepithelial neoplasia Cohort Studies Risk Factors Internal medicine medicine Humans Prospective Studies Cervical Intraepithelial Neoplasia Papillomaviridae Prospective cohort study Cervix Gynecology biology business.industry Papillomavirus Infections Smoking Obstetrics and Gynecology General Medicine Odds ratio Uterine Cervical Dysplasia biology.organism_classification medicine.disease Squamous intraepithelial lesion Logistic Models medicine.anatomical_structure Carcinoma Squamous Cell Female business Follow-Up Studies Cohort study |
| Zdroj: | Tolstrup, J, Munk, C, Thomsen, B L, Svare, E, van den Brule, A J C, Grønbaek, M, Meijer, C & Kjaer Krüger, S 2006, ' The role of smoking and alcohol intake in the development of high-grade squamous intraepithelial lesions among high-risk HPV-positive women ', Acta Obstetricia et Gynecologica Scandinavica, vol. 85, no. 9, pp. 1114-9 . https://doi.org/10.1080/00016340600677027 |
| ISSN: | 1600-0412 0001-6349 |
| DOI: | 10.1080/00016340600677027 |
| Popis: | Udgivelsesdato: 2006-null BACKGROUND: Infection with human papillomavirus is considered a necessary factor in developing high-grade squamous intraepithelial lesions of the cervix. However, most human papillomavirus positive women do not develop high-grade squamous intraepithelial lesions and other factors may be important for this transition. The objective of the present study was to examine if smoking and alcohol intake are associated with the risk of developing high-grade squamous intraepithelial lesions in women positive for high-risk human papillomavirus types. METHODS: We used baseline information on exposures on 548 high-risk human papillomavirus positive women with normal cytology, comparing 94 women who developed high-grade squamous intraepithelial lesions with 454 women who remained cytologically normal. Logistic regression was applied for statistical analysis. RESULTS: Compared with never smokers, the odds ratio for high-grade squamous intraepithelial lesions among current smokers was 1.99 (95% CI: 1.21-3.28). Among current smokers, number of cigarettes, years of smoking, and early age at smoking initiation were associated with increased risk. However, when modeled simultaneously, it seemed that smoking duration and age at smoking initiation were more associated with risk of high-grade squamous intraepithelial lesions than amount of smoking. Alcohol intake was not associated with risk of high-grade squamous intraepithelial lesions among these women. CONCLUSION: Smoking is associated with an increased risk of developing high-grade squamous intraepithelial lesions in women who are infected with oncogenic human papillomavirus. |
| Databáze: | OpenAIRE |
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