Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

Autor:	Lihong Hu, Hongzhi Qiao, Chengli Yu, Lei Zhang, Simin Li, Jing Chen, Meng Zhao, Xuyu Zhu, Zijian Guo, Lina Gao
Rok vydání:	2020
Předmět:	Cell Survival Photothermal Therapy Surface Properties Biomedical Engineering Tumor penetration Cancer therapy chemistry.chemical_element Antineoplastic Agents chemistry.chemical_compound Mice Cell Line Tumor Hyaluronic acid Animals General Materials Science Hyaluronic Acid Particle Size health care economics and organizations Cell Proliferation Copper complex Nanocomposite Nanotubes Chemistry General Chemistry General Medicine Photothermal therapy Combinatorial chemistry Copper Nanorod Gold Drug Screening Assays Antitumor
Zdroj:	Journal of materials chemistry. B. 8(22)
ISSN:	2050-7518
Popis:	We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e40de6e6e8e812e4ff285f9264dfdbc https://pubmed.ncbi.nlm.nih.gov/32108202 Zobrazit plný text záznamu