| Autor: |
Dhima, Irida Th., Peschos, Dimitrios, Simos, Yannis V., Gkiouli, Maria I., Palatianou, Maria E., Ragos, Vasilios N., Kalfakakou, Vasiliki, Evangelou, Angelos M., Karkabounas, Spyridon Ch. |
| Rok vydání: |
2017 |
| Předmět: |
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| DOI: |
10.6084/m9.figshare.5139736.v1 |
| Popis: |
The aim of this study was to investigate the cytotoxic effect cisplatin in combination with epigallocatechin-3-gallate (EGCG) on leiomyosarcoma cells (LMS cells) in order to identify a less toxic but equally effective alternative. Assays for cell proliferation, colony formation efficiency, induction of apoptosis and cell cycle arrest were performed using the IC50 of cisplatin (8.6 μΜ) as a reference value and a concentration of EGCG (30 μΜ) that caused a non-significant reduction in cell proliferation. Pre-treatment of cells with EGCG for 24 h before the addition of cisplatin increased cytotoxicity up to 8.5% (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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