Impaired retrograde transmission of vasodilatory signals via the endothelium in pre-eclampsia: a cause of reduced tissue blood flow?
| Autor: | Suren R. Sooranna, Mark R. Johnson, Mark H.F. Sullivan, J. Gamble, N. Anim-Nyame, Philip J. Steer |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Endothelium Vascular Cell Adhesion Molecule-1 Vasodilation Preeclampsia Pre-Eclampsia Pregnancy Internal medicine E-selectin medicine Plethysmograph Humans Leg Eclampsia biology business.industry General Medicine Blood flow medicine.disease Intercellular Adhesion Molecule-1 Endothelial stem cell medicine.anatomical_structure Regional Blood Flow Immunology biology.protein Cardiology Female Endothelium Vascular business E-Selectin Signal Transduction |
| Zdroj: | Clinical science (London, England : 1979). 106(1) |
| ISSN: | 0143-5221 |
| Popis: | There is evidence that tissue blood flow is regulated by retrograde transmission of signals initiated at capillary and post-capillary sites, and transmitted via the endothelium to modulate pre-capillary resistance. We have used pre-eclampsia as a model to test the hypothesis that normal endothelium is required to enable adjustment of blood flow to match tissue requirements. Integrity of the endothelial pathway was assessed by measuring calf blood flow at increasing venous pressures, using an established small cumulative-step venous-congestion plethysmography protocol in ten women with pre-eclampsia, 17 normal pregnant controls and ten non-pregnant women. Endothelial cell activation was assessed by measuring plasma levels of the cell adhesion molecules, intercellular cell-adhesion molecule-1 (ICAM-1), vascular cell-adhesion molecule-1 (VCAM-1) and E-selectin. Baseline calf blood flow was significantly lower in pre-eclampsia than in the other two groups (P |
| Databáze: | OpenAIRE |
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