Folic acid and Vitamin E supplementation effects on homocysteinernia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients
| Autor: | Deodato, Assanelli, Andrea, Bonanome, Alessandro, Pezzini, Fabio, Albertini, Paola, Maccalli, Pietro, Maccalli, Mario, Grassi, Silvana, Archetti, Riccardo, Negrini, Roberto, Negrini, Francesco, Visioli |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Genetic Markers Male medicine.medical_specialty Antioxidant Endothelium Homocysteine medicine.medical_treatment Hyperhomocysteinemia Myocardial Infarction Vasomotion Antioxidants Drug Administration Schedule chemistry.chemical_compound Folic Acid Gene Frequency Internal medicine medicine Humans Vitamin E Myocardial infarction Endothelial dysfunction Diagnostic Techniques and Procedures Methylenetetrahydrofolate Reductase (NADPH2) Pharmacology business.industry Middle Aged medicine.disease Surgery Uric Acid Vasodilation medicine.anatomical_structure Endocrinology chemistry Dietary Supplements Pharmacology Clinical Myocardial infarction complications Female Endothelium Vascular business |
| Popis: | We examined the effects of folate (either alone or co-supplemented with Vitamin E) on endothelial function in hyperhomocysteinimic patients and correlated results with serum antioxidant capacity. A randomized trial was carried out in 30 young patients with recent acute myocardial infarction (AMI) and high plasma homocysteine concentrations. Intervention consisted of high doses of folate, either alone (group A) or in combination with Vitamin E (group B), for three months. Main outcome measures were endothelial function, serum antioxidant capacity, and homocysteinemia. Folic acid treatment reduced plasma homocysteine concentrations in both groups by 41% and, as compared with baseline values, was associated with a significant (P |
| Databáze: | OpenAIRE |
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