Late effects in adult survivors of childhood cancer
| Autor: | Aleida Postma, Ria Blaauwbroek, Willem Kamps, Klaas H. Groenier, B. Meyboom-de Jong |
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| Přispěvatelé: | Science in Healthy Ageing & healthcaRE (SHARE) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Moderate to severe
Adult Male Pediatrics medicine.medical_specialty Time Factors CLINICAL CARE childhood cancer survivors Childhood cancer long-term follow-up Disease ADOLESCENT THERAPY DISEASE Hospitals University HRQoL Quality of life Predictive Value of Tests QUALITY-OF-LIFE Neoplasms TOMOGRAPHY Medicine Health Status Indicators Humans Survivors Adverse effect Child Netherlands Probability HEALTH-STATUS business.industry Cancer Common Terminology Criteria for Adverse Events EDUCATION Hematology Middle Aged medicine.disease grading of late effects humanities Oncology El Niño Child Preschool Quality of Life Female business Needs Assessment Follow-Up Studies |
| Zdroj: | Annals of Oncology, 18(11), 1898-1902. Oxford University Press |
| ISSN: | 0923-7534 |
| Popis: | Background: To assess health status and health-related quality of life (HRQoL) in childhood cancer survivors who were not involved in regular long-term follow-up.Patients and methods: One hundred and twenty-three long-term survivors, median age 33 (19-50) years, follow-up 27 (9-38) years, were recalled to the long-term follow-up clinic. Most of them were treated in the period 1970-1990. Late effects were graded using the Common Terminology Criteria for Adverse Events, version 3 (CTCAEv3). HRQoL was assessed by RAND-36. Socio-economic factors were compared with data from Statistics Netherlands (CBS).Results: Grade 1-2 late effects were found in 54% of the survivors, grade 3-4 in 39%, two or more late effects in 70% and grade 2-4 previously unknown late effects in 33%. Survivors had significantly lower scores on RAND-36 compared with controls.Conclusions: As nearly 40% of these long-term childhood cancer survivors suffer from moderate to severe late effects and 33% had previously unknown late effects it is worthwhile recalling these patients to follow-up. Where and by whom this follow-up can best be done is still a question that needs to be answered. |
| Databáze: | OpenAIRE |
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