Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men
| Autor: | Benedetta Beltrame, C. Corno, L Presenti, Marcello Lucchese, Linda Vignozzi, Andrea Galli, Paolo Comeglio, M C Truglia, Mario Maggi, Farid Saad, Tommaso Mello, Elisa Maseroli, Elena Rapizzi, Sandra Filippi, Francesco Lotti, Ilaria Cellai, Giulia Rastrelli, Enrico Facchiano |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Biopsy Adipose tissue Intra-Abdominal Fat Protective Agents Asymptomatic chemistry.chemical_compound Endocrinology Non-alcoholic Fatty Liver Disease Internal medicine NAFLD Nonalcoholic fatty liver disease medicine Humans Testosterone Obesity Triglyceride business.industry Hypogonadism Middle Aged medicine.disease Lipid Metabolism Mitochondria Cross-Sectional Studies Treatment Outcome chemistry Italy Liver Adipogenesis Original Article medicine.symptom Steatosis Insulin Resistance business |
| Zdroj: | Journal of Endocrinological Investigation |
| ISSN: | 1720-8386 |
| Popis: | Purpose In both preclinical and clinical settings, testosterone treatment (TTh) of hypogonadism has shown beneficial effects on insulin sensitivity and visceral and liver fat accumulation. This prospective, observational study was aimed at assessing the change in markers of fat and liver functioning in obese men scheduled for bariatric surgery. Methods Hypogonadal patients with consistent symptoms (n = 15) undergoing 27.63 ± 3.64 weeks of TTh were compared to untreated eugonadal (n = 17) or asymptomatic hypogonadal (n = 46) men. A cross-sectional analysis among the different groups was also performed, especially for data derived from liver and fat biopsies. Preadipocytes isolated from adipose tissue biopsies were used to evaluate insulin sensitivity, adipogenic potential and mitochondrial function. NAFLD was evaluated by triglyceride assay and by calculating NAFLD activity score in liver biopsies. Results In TTh-hypogonadal men, histopathological NAFLD activity and steatosis scores, as well as liver triglyceride content were lower than in untreated-hypogonadal men and comparable to eugonadal ones. TTh was also associated with a favorable hepatic expression of lipid handling-related genes. In visceral adipose tissue and preadipocytes, TTh was associated with an increased expression of lipid catabolism and mitochondrial bio-functionality markers. Preadipocytes from TTh men also exhibited a healthier morpho-functional phenotype of mitochondria and higher insulin-sensitivity compared to untreated-hypogonadal ones. Conclusions The present data suggest that TTh in severely obese, hypogonadal individuals induces metabolically healthier preadipocytes, improving insulin sensitivity, mitochondrial functioning and lipid handling. A potentially protective role for testosterone on the progression of NAFLD, improving hepatic steatosis and reducing intrahepatic triglyceride content, was also envisaged. Clinical Trial Registration ClinicalTrials.gov Identifier: NCT02248467, September 25th 2014 |
| Databáze: | OpenAIRE |
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