Synthesis of novel 4′-acylamino modified 21 E -benzylidene steroidal derivatives and their cytotoxic activities
| Autor: | Yuan-Feng Li, Jin-Ming Gao, Jiang-Jiang Tang, Ning-Juan Fan, Yang-Yang Han |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Antineoplastic Agents Brine shrimp Chemistry Techniques Synthetic 01 natural sciences Biochemistry HeLa 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnadienes Animals Humans Cytotoxic T cell Moiety Cytotoxicity Molecular Biology Pharmacology biology 010405 organic chemistry Chemistry Organic Chemistry biology.organism_classification In vitro 0104 chemical sciences Cell culture 030220 oncology & carcinogenesis MCF-7 Cells Artemia Artemia salina HeLa Cells |
| Zdroj: | Steroids. 123:20-26 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/j.steroids.2017.04.006 |
| Popis: | A series of 4'-acylamino modified Δ1,4-pregnadien-21E-benzylidene-3,20-dione derivatives (6a-v) was synthesized from the commercially available progesterone (1). These title compounds were evaluated for their toxicity against brine shrimp (Artemia salina) and cytotoxic activities against two human cancer cell lines (HeLa and MCF-7). The results revealed that compound 6f exhibited promising in vitro cytotoxic activity to the two cancer cell lines and the nature of acylamino functional group in the benzylidene moiety had a significant influence on cytotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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