Serum Visfatin - A Novel Marker of Chronic Kidney Disease
| Autor: | N Sasivathanam, A Arshiya Begum, N Santhi, K Vanitha, S Syed Ali Fathima, K. Nirmala Devi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Very low-density lipoprotein
medicine.medical_specialty high sensitive c reactive protein medicine.diagnostic_test biology business.industry visfatin lcsh:R C-reactive protein lcsh:Medicine Adipose tissue Renal function medicine.disease Gastroenterology chemistry.chemical_compound High-density lipoprotein chemistry Low-density lipoprotein Internal medicine medicine biology.protein Lipid profile business chronic kidney disease Kidney disease |
| Zdroj: | Journal of Medical Sciences and Health, Vol 3, Iss 1, Pp 19-25 (2017) |
| ISSN: | 2394-949X 2394-9481 |
| DOI: | 10.46347/jmsh.2017.v03i01.004 |
| Popis: | BACKGROUND: Chronic Kidney Disease (CKD) is defined as Glomerular Filteration Rate < 60ml/min/1.73m2 for a minimum of 3 months irrespective of the cause. Accelerated atherosclerosis is the main cause of morbidity and mortality in CKD patients. Visfatin is a 52KDa protein predominantly secreted by the visceral adipose tissue which has anti-inflammatory, Insulin-mimetic and antiapoptotic activities. AIMS AND OBJECTIVE: To estimate the levels of serum Visfatin in patients with CKD and to compare it with serum hsCRP (high sensitive C reactive protein), Ccr(Creatinine clearance) and lipid profile. MATERIALS AND METHODS: The study was conducted at Thanjavur Medical College Hospital. 50 patients of CKD as cases and 50 age and gender matched healthy individuals were selected as cases and controls respectively.Serum Visfatin and Serum hsCRP were estimated by Enzyme Immune Assay and Immunoturbidimetric method respectively. Serum Total Cholesterol (TC), Triglycerides (TGL), Very Low Density Lipoprotein(VLDL-C), High Density Lipoprotein (HDL-C) were estimated by enzymatic method. Creatinine Clearance (Ccr)and Low Density Lipoprotein (LDL-C) were calculated using formula. RESULTS: The mean value of Visfatin in cases and controls were 27.42±8.92 and 10.62±1.57 ng/ml (t=13.11; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|