Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease

Autor: Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Júnior, Francesco Landi, Roberto Bernabei, Roberta Romano, Cecilia Bucci, Emanuele Marzetti
Přispěvatelé: Picca, A., Guerra, F., Calvani, R., Coelho-Junior, H. J., Landi, F., Bernabei, R., Romano, R., Bucci, C., Marzetti, E.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
lcsh:Immunologic diseases. Allergy
Quality control system
Immunology
Endocytic cycle
Inflammation
Review
Endosomes
Mitochondrion
Biology
damage-associated molecular pattern
mitochondrial-derived vesicle
Extracellular Vesicles
03 medical and health sciences
0302 clinical medicine
mitochondrial-derived vesicles
medicine
Extracellular
Alarmins
Animals
Humans
Immunology and Allergy
damage-associated molecular patterns
innate immunity
Tissue homeostasis
Innate immune system
Neurodegeneration
Settore MED/09 - MEDICINA INTERNA
quality control system
medicine.disease
Immunity
Innate
Mitochondria
Cell biology
Protein Transport
030104 developmental biology
inflammation
Parkinson’s disease
medicine.symptom
Lysosomes
lcsh:RC581-607
Alzheimer’s disease
endo-lysosomal system
Intracellular
Signal Transduction
030215 immunology
Zdroj: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.601740/full
Popis: Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer's and Parkinson's disease).
Databáze: OpenAIRE
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