Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
| Autor: | Jasmine Rios, Laurens Holmes, Jacqueline A. Benson, Betyna Berice, Daniel Halloran, Kadedrah V. Parson, Nastocia T. Bafford |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Helicobacter pylori (H. pylori) Qualitative evidence lcsh:Medicine Gastric carcinoma Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine gastric carcinoma General Environmental Science gastric ulceration biology business.industry lcsh:R General Engineering gastritis Cancer Helicobacter pylori biology.organism_classification medicine.disease Environmental effect QES 030220 oncology & carcinogenesis General Earth and Planetary Sciences 030211 gastroenterology & hepatology Cancer development Gastritis medicine.symptom business |
| Zdroj: | Medicines Volume 8 Issue 1 Medicines, Vol 8, Iss 1, p 1 (2021) |
| ISSN: | 2305-6320 |
| DOI: | 10.3390/medicines8010001 |
| Popis: | Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development. |
| Databáze: | OpenAIRE |
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