Nitric oxide in septic shock
| Autor: | Michael A. Titheradge |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Endothelium Biophysics Nitric Oxide Synthase Type II Apoptosis Cardiovascular Biochemistry Nitric oxide chemistry.chemical_compound Endotoxin Internal medicine Septic shock medicine Animals Humans Cause of death biology business.industry Cell Biology medicine.disease Shock Septic Nitric oxide synthase medicine.anatomical_structure Endocrinology chemistry Models Chemical Liver Shock (circulatory) Enzyme Induction Immunology biology.protein Endothelium Vascular medicine.symptom Nitric Oxide Synthase business Surgical patients Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1411(2-3):437-455 |
| ISSN: | 0005-2728 |
| DOI: | 10.1016/s0005-2728(99)00031-6 |
| Popis: | Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock. |
| Databáze: | OpenAIRE |
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