Right ventricular morphology and function in chronic obstructive pulmonary disease patients living at high altitude
| Autor: | Sami İlhan, Nurten Sayar, Gokhan Perincek, Binnaz Zeynep Yıldırım, Tolga Sinan Güvenç, Seref Kul, Hatice Betül Erer, Yavuz Karabağ, Coskun Dogan, Mehmet Eren, Bahattin Balcı |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Heart Ventricles Pulmonary function testing Pulmonary Disease Chronic Obstructive Internal medicine medicine.artery Hypoxic pulmonary vasoconstriction Medicine Humans Arterial Pressure Hypoxia Aged COPD business.industry Chronic obstructive pulmonary disease Effects of high altitude on humans Hypoxia (medical) Middle Aged medicine.disease respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Blood pressure Ventricle Echocardiography Pulmonary artery Cardiology Ventricular Function Right Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart, lungcirculation. 22(1) |
| ISSN: | 1444-2892 |
| Popis: | Introduction Pulmonary vasculature is affected in patients with chronic pulmonary obstructive disease (COPD). As a result of increased pulmonary resistance, right ventricular morphology and function are altered in COPD patients. High altitude and related hypoxia causes pulmonary vasoconstriction, thereby affecting the right ventricle. We aimed to investigate the combined effects of COPD and altitude-related chronic hypoxia on right ventricular morphology and function. Materials and Methods Forty COPD patients living at high altitude (1768 m) and 41 COPD patients living at sea level were enrolled in the study. All participants were diagnosed as COPD by a pulmonary diseases specialist depending on symptoms, radiologic findings and pulmonary function test results. Detailed two-dimensional echocardiography was performed by a cardiologist at both study locations. Results Oxygen saturation and mean pulmonary artery pressure were higher in the high altitude group. Right ventricular end diastolic diameter, end systolic diameter, height and end systolic area were significantly higher in the high altitude group compared to the sea level group. Parameters of systolic function, including tricuspid annular systolic excursion, systolic velocity of tricuspid annulus and right ventricular isovolumic acceleration were similar between groups, while fractional area change was significantly higher in the sea level groups compared to the high altitude group. Indices of diastolic function and myocardial performance index were similar between groups. Conclusion An increase in mean pulmonary artery pressure and right ventricular dimensions are observed in COPD patients living at high altitude. Despite this increase, systolic and diastolic functions of the right ventricle, as well as global right ventricular performance are similar in COPD patients living at high altitude and sea level. Altitude-related adaptation to chronic hypoxia could explain these findings. |
| Databáze: | OpenAIRE |
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