Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
| Autor: | Manuel A. Patarroyo, Jose Rojas-Caraballo, Diana I. Angel, Alvaro Mongui, Oscar Perez-Leal, Jimena Cortés |
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| Rok vydání: | 2007 |
| Předmět: |
Molecular Sequence Data
Plasmodium falciparum Plasmodium vivax Protozoan Proteins Biophysics Antigens Protozoan Biochemistry Mice Exon Species Specificity parasitic diseases Animals Plasmodium berghei Amino Acid Sequence Cloning Molecular Molecular Biology Gene Microscopy Confocal Models Genetic biology Rhoptry Exons Sequence Analysis DNA Cell Biology biology.organism_classification Virology biology.protein Rabbits Antibody Plasmodium yoelii |
| Zdroj: | Biochemical and Biophysical Research Communications. 358:861-866 |
| ISSN: | 0006-291X |
| Popis: | Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite's asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins. |
| Databáze: | OpenAIRE |
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