Infliximab Does Not Lead to Reduction in the Interferon-gamma and Lymphoproliferative Responses of Patients with Moderate to Severe Psoriasis
| Autor: | L. C. Silva, Luciena C M Ortigosa, Alberto José da Silva Duarte, Gil Benard, Maria D F Takahashi |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Lymphocyte Cytomegalovirus chemical and pharmacologic phenomena Dermatology Lymphocyte Activation Severity of Illness Index Enterotoxins Interferon-gamma Young Adult Immune system Psoriasis medicine Superantigen Humans Interferon gamma Phytohemagglutinins Cells Cultured Aged Phytohaemagglutinin Antigens Bacterial Immunity Cellular biology Tumor Necrosis Factor-alpha business.industry Anti-Inflammatory Agents Non-Steroidal Antibodies Monoclonal General Medicine Middle Aged medicine.disease Infliximab medicine.anatomical_structure Immunology Leukocytes Mononuclear biology.protein Female Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | Acta Dermato Venereologica. 94:26-31 |
| ISSN: | 0001-5555 |
| DOI: | 10.2340/00015555-1650 |
| Popis: | Treatment of patients with immune-mediated inflammatory diseases with anti-tumour necrosis factor (anti-TNF) agents increases the risk of tuberculosis reactivation, suggesting that it may affect their cellular immune responses. We evaluated cellular immune responses of 12 severe psoriasis patients before and during infliximab treatment. Peripheral blood mononuclear cells were stimulated with phytohaemagglutinin, the superantigen enterotoxin B (SEB), a cytomegalovirus lysate (CMV), and Mycobacterium tuberculosis (Mtb) antigens. The lymphocyte proliferative and IFN-γ responses were evaluated. Treatment with infliximab did not lead to reduction in the IFN-γ and lymphoproliferative responses: it rather increased the overnight release of IFN-γ in phytohaemagglutinin and SEB stimulated cultures. This effect was most noted at the peak of the anti-TNF clinical effect and less prominent at its nadir. Immunoreactivity to CMV was also either unaffected or slightly increased by the anti-TNF. Of note, the IFN-γ and proliferative responses to Mtb by the two tuberculin skin test-reactors were also increased at the peak of infliximab, declining at its nadir. The deleterious consequences of TNF blockade in severe psoriasis patients undergoing infliximab treatment are apparently attenuated by the abbreviation of the immunosuppressive effect of TNF overexpression. |
| Databáze: | OpenAIRE |
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