Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals
| Autor: | Dan Mellström, Reinhold G. Erben, Ann Hammarstedt, Lars Lind, Tobias E. Larsson, Majd A.I. Mirza, Magnus Karlsson, Östen Ljunggren, Richard Marsell, Eric S. Orwoll, Claes Ohlsson, Åsa Tivesten, Johan Alsiö, Karl Michaëlsson |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Leptin Male Fibroblast growth factor 23 medicine.medical_specialty Blood lipids Risk Assessment Body Mass Index Absorptiometry Photon Waist–hip ratio Risk Factors Diabetes mellitus Internal medicine Humans Insulin Medicine Prospective Studies Adiposity Aged Dyslipidemias Metabolic Syndrome Sweden biology Waist-Hip Ratio business.industry Age Factors medicine.disease Lipids Up-Regulation Fibroblast Growth Factors Fibroblast Growth Factor-23 Cross-Sectional Studies Logistic Models Endocrinology Cardiovascular Diseases Linear Models biology.protein Female Apolipoprotein A1 Adiponectin Waist Circumference Metabolic syndrome Cardiology and Cardiovascular Medicine business Body mass index Biomarkers Dyslipidemia |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 31:219-227 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Objective— Disturbances in mineral metabolism define an increased cardiovascular risk in patients with chronic kidney disease. Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease. Because other members of the FGF family play a role in lipid and glucose metabolism, we hypothesized that FGF23 would associate with metabolic factors that predispose to an increased cardiovascular risk. The goal of this study was to investigate the relationship between FGF23 and metabolic cardiovascular risk factors in the community. Methods and Results— Relationships between serum FGF23 and body mass index (BMI), waist circumference, waist-to-hip ratio, serum lipids, and fat mass were examined in 2 community-based, cross-sectional cohorts of elderly whites (Osteoporotic Fractures in Men Study: 964 men aged 75±3.2; Prospective Investigation of the Vasculature in Uppsala Seniors study: 946 men and women aged 70). In both cohorts, FGF23 associated negatively with high-density lipoprotein and apolipoprotein A1 (7% to 21% decrease per 1-SD increase in log FGF23; P P P P P Conclusion— We report for the first time on associations between circulating FGF23, fat mass, and adverse lipid metabolism resembling the metabolic syndrome, potentially representing a novel pathway(s) linking high FGF23 to an increased cardiovascular risk. |
| Databáze: | OpenAIRE |
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