Hepatic Cholesterol-Lipid Anomalies Induced by Aflatoxin
| Autor: | F. T. Lynd, J. Q. Lynd |
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| Rok vydání: | 1970 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine medicine.medical_specialty Aflatoxin Time Factors Oleic Acids Palmitic Acids Biology 010603 evolutionary biology 01 natural sciences Palmitic acid 03 medical and health sciences chemistry.chemical_compound Aflatoxins Internal medicine Blood plasma medicine Animals Mycotoxin Triglycerides Cholesterol Body Weight food and beverages Lipid metabolism Organ Size General Medicine 030108 mycology & parasitology Hyperplasia medicine.disease Lipids Acute toxicity Ducks Endocrinology Linoleic Acids Liver chemistry Biochemistry Female Microscopy Polarization Stearic Acids |
| Zdroj: | Pathologia veterinaria. 7:509-516 |
| ISSN: | 0031-2975 |
| DOI: | 10.1177/030098587000700606 |
| Popis: | Degeneration of hepatic parenchymal cells and hyperplasia of biliary ducts are the characteristic lesions associated with acute poisoning by aflatoxin in animals. This method of assessing exposure to the aflatoxins is very limited at lower concentrations of the toxins and this has been well recognized by a number of investigators13 11713. The objectives of this study were to determine progressive, quantitative changes in hepatic lipid components of duckling that could be correlated with sublethal doses of aflatoxins. Previous studies have demonstrated that 2 soil microfloral associations, n/lircor and Trickodernza, are antagonistic to strains of moIds which synthesize mycotoxins83 12. White Pckin ducklings that have received extracts of mycelia of these genera and their media in the ration subscquently had significantly greater tolerance to aflatoxin as measured by alterations in growth, hepatic structure, bile, and lipid and cholesterol in blood plasma. Factors which influencc the sensitivity of ducklings to aflatoxins are : age, breed, ration, preconditioning, thc vehicle used as a solvent for extraction and purification of aflatoxins, and the fractions of the aflatoxins2. 9. 5. ti. 9. 14. 15. 17. 2:). 21 |
| Databáze: | OpenAIRE |
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