High seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population
| Autor: | Harald Heider, Cornelia Feiterna-Sperling, Christoph Königs, K. Weizsäcker, Bernd Buchholz, Jörg Hofmann, Josef Eberle, Barbara Gärtner, Nikola Hanhoff, Gundula Notheis, Detlev H. Krüger, Renate Krüger |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Pediatrics medicine.medical_specialty Adolescent Cross-sectional study viruses Immunology Population Emigrants and Immigrants HIV Infections Antibodies Viral 03 medical and health sciences 0302 clinical medicine Risk Factors Seroepidemiologic Studies medicine Ethnicity Immunology and Allergy Seroprevalence Humans 030212 general & internal medicine Risk factor education Child Kaposi's sarcoma Immunodeficiency education.field_of_study business.industry virus diseases Infant General Medicine Odds ratio Herpesviridae Infections medicine.disease 030104 developmental biology Cross-Sectional Studies Child Preschool Herpesvirus 8 Human Coinfection Female business |
| Zdroj: | Medical microbiology and immunology. 205(5) |
| ISSN: | 1432-1831 |
| Popis: | Human herpesvirus-8 (HHV-8) is the etiological agent of Kaposi's sarcoma (KS), which primarily affects human immunodeficiency virus (HIV)-infected adults with advanced immunodeficiency. Currently, only limited prevalence data for HHV-8 infection in HIV-infected children living in non-endemic areas are available. This multicenter cross-sectional study was conducted in four university hospitals in Germany specializing in pediatric HIV care. Stored serum specimens obtained from 207 vertically HIV-1-infected children and adolescents were tested for antibodies against lytic and latent HHV-8 antigens. Logistic regression was used to assess independent risk factors associated with HHV-8 seropositivity. The overall HHV-8 seroprevalence was 24.6 % (n = 51/207) without significant differences related to sex, age, or ethnicity. In univariate analysis, HHV-8 seropositivity was significantly associated with a child having being born outside Germany, maternal origin from sub-Saharan Africa, a history of breastfeeding, CDC immunologic category 3, and deferred initiation of antiretroviral therapy (>24 months of age). In multivariate analysis, a child's birth outside Germany was the only significant risk factor for HHV-8 seropositivity (odds ratio 3.98; 95 % confidence interval 1.27-12.42). HHV-8-associated malignancies were uncommon; only one patient had a history of KS. Serum specimen of vertically HIV-infected children and adolescents living in Germany showed a high HHV-8 seroprevalence. These findings suggest that primary HHV-8 infection-a risk factor for KS and other HHV-8-associated malignancies-occurs early in life. Thus, management of perinatally HIV-infected children should include testing for HHV-8 coinfection and should consider future risks of HHV-8-associated malignancies. |
| Databáze: | OpenAIRE |
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