Reproducibility of the blood flow index as noninvasive, bedside estimation of cerebral blood flow
| Autor: | Bendicht Peter Wagner, Roland A. Ammann, Susanne Gertsch, Juerg Pfenninger |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Heart Defects
Congenital Indocyanine Green Time Factors Critical Care Point-of-Care Systems Intensive Care Units Pediatric Critical Care and Intensive Care Medicine chemistry.chemical_compound Blood Circulation Time Central Nervous System Diseases Humans Medicine Prospective Studies Child Monitoring Physiologic Brain Diseases Reproducibility Spectroscopy Near-Infrared business.industry Patient Selection Infant Newborn Infant Blood flow Meconium Aspiration Syndrome Cerebral blood flow chemistry Brain Injuries Cerebrovascular Circulation Child Preschool Anesthesia Feasibility Studies business Indocyanine green Blood Flow Velocity Biomedical engineering |
| Zdroj: | Intensive Care Medicine. 29:196-200 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s00134-002-1592-z |
| Popis: | To investigate the feasibility and reproducibility of the blood flow index (BFI) method for measuring cerebral blood flow.Prospective functional study in pediatric intensive care.14 consecutive patients with median age of 2 months (range 1 days-11 years) requiring artificial ventilation, invasive arterial blood pressure monitoring, and central venous access.The first passage of an intravenous indocyanine green (ICG) bolus through the cerebral vasculature was monitored by noninvasive near-infrared spectroscopy. BFI was calculated by dividing maximal ICG absorption change by rise time. Reproducibility was evaluated by six ICG injections at 5-min intervals.Of all ICG injections 6% were canceled, and 4% were eliminated due to injection failures. Median BFI of 17 reproducibility determinations was 71 (range 12-213) and median coefficient of variation (CV) of BFI was 10% (4.9-18.5). The quantity of ICG bolus did not affect the CV (0.1 vs. 0.3 mg ICG/kg). Eight reproducibility tests in patients after cardiac surgery had smaller CV than the others, and the eight in newborns had higher CV than in older children. Patient parameters such as arterial blood pressure, endtidal CO(2), and percutaneous oxygen saturation were stable and showed CV below 2% during reproducibility determination.The BFI method allows rapid and repeated measurements of CBF with good feasibility and reproducibility. As a relative but not absolute measure of CBF, BFI seems to be suited for clinical evaluation of intraindividual CBF changes during determination of cerebrovascular reactivities or during therapeutic interventions. |
| Databáze: | OpenAIRE |
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