Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study
| Autor: | Christian Bach, H. Tilg, Augusto Vaglio, Jan Bremer, Alexander R. Moschen, Davide Martorana, Stefan Wieczorek, Bernd M. Spriewald, Thomas Neumann, Jochen Zwerina, Frank Moosig, Georg Schett, Guido Hegasy, Maria Jatzwauk |
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| Rok vydání: | 2011 |
| Předmět: |
Eotaxin
medicine.medical_specialty Single-nucleotide polymorphism Churg-Strauss Syndrome Polymorphism Single Nucleotide Antibodies Antineutrophil Cytoplasmic Diagnosis Differential Rheumatology Predictive Value of Tests immune system diseases Internal medicine Hypereosinophilic Syndrome Eosinophilic Parasitic Diseases otorhinolaryngologic diseases Genetic predisposition Humans Medicine Pharmacology (medical) Immunogenetic Phenomena Connective Tissue Diseases Receiver operating characteristic Chemokine CCL26 business.industry respiratory system respiratory tract diseases surgical procedures operative ROC Curve Chemokines CC Immunology Biomarker (medicine) Colitis Ulcerative CCL26 business Biomarkers |
| Zdroj: | Rheumatology. 50:1823-1827 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/keq445 |
| Popis: | Objectives. To determine the potential of eotaxin-3 as a diagnostic marker for active disease and genetic susceptibility factor for Churg-Strauss syndrome (CSS). Methods. A total of 37 patients with active, relapsed or inactive CSS, 123 healthy controls and 138 disease controls were studied. Clinical data were collected and serum levels of eotaxin-3 were determined. Ex vivo stability of eotaxin-3 in serum samples was tested. Furthermore, the association of single nucleotide polymorphisms (SNPs) in the eotaxin-3 gene with CSS was determined in 161 CSS patients and 124 healthy controls. Results. Serum eotaxin-3 was highly elevated in active CSS patients. Neither eosinophilic diseases nor other small-vessel vasculitides were associated with high serum eotaxin-3 levels. Receiver operating characteristic curve analysis determined a sensitivity and specificity of 87.5 and 98.6% at a cut-off level of 80 pg/ml. None of the tested SNPs within the eotaxin-3 gene influenced the susceptibility to develop CSS. Conclusions. Serum eotaxin-3 is a sensitive and specific marker for the diagnosis of active CSS suitable for routine clinical practice. Previously described SNPs in the eotaxin-3 gene do not predict the risk of developing CSS. |
| Databáze: | OpenAIRE |
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