Cilomilast: Orally Active Selective Phosphodiesterase-4 Inhibitor for Treatment of Chronic Obstructive Pulmonary Disease
| Autor: | Kimi S. Vesta, Shaunta' D Martina, Maha S Ismail |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Cyclohexanecarboxylic Acids Phosphodiesterase Inhibitors Carboxylic Acids MEDLINE Administration Oral 030204 cardiovascular system & hematology Cochrane Library 030226 pharmacology & pharmacy Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Internal medicine Nitriles medicine Humans Pharmacology (medical) Adverse effect COPD business.industry Cilomilast Respiratory disease medicine.disease Cyclic Nucleotide Phosphodiesterases Type 4 Surgery Clinical trial 3' 5'-Cyclic-AMP Phosphodiesterases business medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 40:1822-1828 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1345/aph.1h049 |
| Popis: | Objective: To review available literature evaluating the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of cilomilast, a selective phosphodiesterase-4 (PDE4) inhibitor. Data Sources: Literature was accessed through MEDLINE (1966–May 2006), Current Contents Clinical Medicine (1998–May 2006), and The Cochrane Library Database (1st quarter 2006) using the terms cilomilast, Ariflo, and SB 207 499. Reference lists from retrieved articles and information from the manufacturer were manually reviewed. Study Selection and Data Extraction: All clinical trials evaluating cilomilast and published in English were included in this review. In addition, articles evaluating the pharmacology, pharmacokinetics, and safety of cilomilast in humans were reviewed. Data Synthesis: Cilomilast is a second-generation PDE4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with chronic obstructive pulmonary disease (COPD). Selective PDE4 inhibition is proposed to maximize the antiinflammatory effects of PDE inhibition while minimizing the adverse effects of nonselective agents. To date, 4 clinical trials have evaluated the efficacy of cilomilast and demonstrated improvement in lung function (forced expiratory volume in 1 second) and quality of life and reduction in the occurrence of COPD exacerbations compared with placebo. Cilomilast is generally well tolerated, with adverse effects being overall mild and self-limiting. Conclusions: COPD is a progressive disease, and available treatment options provide limited efficacy. Given its unique mechanism of action and improved adverse effect profile compared with previous agents, cilomilast may have a promising role for the management of COPD. |
| Databáze: | OpenAIRE |
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