Postdiagnostic Mediterranean and Healthy Nordic Dietary Patterns Are Inversely Associated with All-Cause Mortality in Long-Term Colorectal Cancer Survivors
| Autor: | Sandra Plachta-Danielzik, Ute Nöthlings, Sabina Waniek, Jochen Hampe, Ilka Ratjen, Wolfgang Lieb, Romina di Giuseppe, Manja Koch, Sabrina Schlesinger, Clemens Schafmayer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Mediterranean climate Male medicine.medical_specialty Mediterranean diet Colorectal cancer Longevity Medicine (miscellaneous) Rectum Diet Mediterranean Diet Surveys White People 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Germany medicine Humans 030212 general & internal medicine Prospective cohort study Nutrition and Dietetics Cancer Middle Aged medicine.disease medicine.anatomical_structure Quartile 030220 oncology & carcinogenesis Female Colorectal Neoplasms Cohort study |
| Zdroj: | The Journal of nutrition. 147(4) |
| ISSN: | 1541-6100 |
| Popis: | Background: Dietary factors are known to affect the risk of new-onset colorectal cancer (CRC), but information on the extent to which postdiagnostic diet affects mortality in long-term CRC survivors is scarce.Objective: We investigated the association of 2 a priori-defined postdiagnostic dietary patterns [Modified Mediterranean Diet Score (MMDS) and healthy Nordic Food Index (HNFI)] with all-cause mortality in long-term CRC survivors.Methods: Diet was assessed at a median time of 6 y after cancer diagnosis in 1404 CRC survivors (median age: 69 y; 56% men) in a prospective cohort study in Northern Germany by using a semiquantitative food-frequency questionnaire. Cox proportional hazard models, adjusting for clinical and sociodemographic characteristics, were used to assess associations of the MMDS and the HNFI with all-cause mortality.Results: A total of 204 patients died during a median follow-up time of 7 y after diet assessment. In multivariable-adjusted models, higher adherence to the modified Mediterranean diet was significantly associated with lower all-cause mortality (HR: 0.48; 95% CI: 0.32, 0.74 for highest compared with lowest score quartile and HR: 0.88; 95% CI: 0.81, 0.96 per 1-point increment in pattern score). Similarly, the HNFI was inversely associated with all-cause mortality when the highest was compared with the lowest index quartile (HR: 0.63; 95% CI: 0.39, 1.04) and when modeled as a continuous trait (HR: 0.90; 95% CI: 0.82, 0.99 per 1-point increment in the score).Conclusions: Our results suggest that higher adherences to the Mediterranean diet and to the healthy Nordic diet after CRC diagnosis are associated with better overall survival in long-term CRC survivors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|