Trace Elements in Chronic Haemodialysis Patients and Healthy Individuals-A Comparative Study
| Autor: | Ezhumalai Govindasamy, Arunkumar Ramachandrappa, Tony Mathew Kadavanu, Lokesh Shanmugam, Shashank Rakesh Tiwari, Amirtha Lakshmi Rajkumar, Siva Ranganathan Green, Hemachandar Radhakrishnan |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Clinical Biochemistry lcsh:Medicine chemistry.chemical_element Disease 010501 environmental sciences 01 natural sciences Gastroenterology Group A endothelial dysfunction Group B End stage renal disease 03 medical and health sciences Statistical significance Internal medicine medicine Endothelial dysfunction 0105 earth and related environmental sciences toxic elements 030102 biochemistry & molecular biology Internal Medicine Section business.industry lcsh:R General Medicine medicine.disease Surgery chemistry inflammation Healthy individuals business Selenium |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 10, Iss 10, Pp OC14-OC17 (2016) |
| Popis: | Introduction: End Stage Renal Disease (ESRD) patients despite receiving adequate Haemodialysis (HD) develop significant risk of Cardiovascular Disease (CVD). Abnormality in levels of trace elements may potentiate vascular injury by producing sustained inflammation and endothelial dysfunction. Hence, the present study was undertaken to evaluate the levels of trace elements in patients receiving HD. Aim: To study the blood levels of arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium among ESRD patients undergoing HD and compare it with healthy individuals. Materials and Methods: It was a cross-sectional, comparative study done in a tertiary care center. About 40 established ESRD patients aged above 18 years, belonging to both sexes, undergoing chronic HD for more than six months were enrolled as Group A (Cases). Patients who had history of smoking and occupational exposure to heavy metals were excluded from the study. About 40 age and sex matched apparently healthy individuals attending health check-up were enrolled as Group B (Controls). Participants of this group had normal e-GFR by Modification of Diet in Renal Disease (MDRD) equation. About 5ml of fasting venous blood sample was obtained from both groups and analyzed for trace elements. Chi-square/ Fisher’s-exact test was used for comparing ratios. A p-value of |
| Databáze: | OpenAIRE |
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