Association of a particular amino acid sequence of the HLA-DR beta 1 chain with HTLV-I-associated myelopathy
| Autor: | Kazumasa Matsuki, Nobutaka Eiraku, Takeshi Tabira, Koichiro Usuku, Katsushi Tokunaga, Masahito Suehara, Keikichi Takahashi, Takeo Juji, Mitsuhiro Osame, Masatoyo Nishizawa |
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| Rok vydání: | 1990 |
| Předmět: |
Immunology
Molecular Sequence Data Biology Polymerase Chain Reaction law.invention immune system diseases law hemic and lymphatic diseases Immunology and Allergy Humans Genetic Predisposition to Disease Amino Acid Sequence Peptide sequence Gene Polymerase chain reaction Alleles Sequence (medicine) Genetics Base Sequence Oligonucleotide Nucleic acid sequence virus diseases Nucleic Acid Hybridization HLA-DR Antigens Paraparesis Tropical Spastic Hypervariable region Htlv i associated myelopathy Oligonucleotide Probes |
| Zdroj: | European journal of immunology. 20(7) |
| ISSN: | 0014-2980 |
| Popis: | Analyses of HLA-DRB1 gene using polymerase chain reaction and sequence-specific oligonucleotide probes reveal that the amino acid sequence Glu-Gln-Arg-Arg-Ala-Ala-Val at positions 69-75 of the third hypervariable region (HVR) of HLA-DR beta 1 chain is significantly associated with HTLV-I-associated myelopathy (HAM). Since the frequency of this sequence in HTLV-I carriers is almost the same as that in controls from Kagoshima (an endemic area of HTLV-I), this sequence may be related to susceptibility to HAM rather than to susceptibility to HTLV-I infection. Since this third HVR functions as putative antigen-binding sites and T cell recognition sites, the amino acid sequence of positions 68-73 was analyzed in detail. The analysis reveals that Gln70 and Arg71 are relevant to the occurrence of HAM. |
| Databáze: | OpenAIRE |
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