Temporal sequence of plaque formation in the cerebral cortex of non-demented individuals
| Autor: | Carolyn M. Coyne, John C. Hunsaker, Huaichen Liu, D. Larry Sparks, Stephen W. Scheff |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Aging Heart disease Coronary Disease Hippocampus Pathology and Forensic Medicine Coronary artery disease Pathogenesis Cellular and Molecular Neuroscience Reference Values medicine Dementia Humans Antigens Aged Aged 80 and over Cerebral Cortex Neurons Vascular disease business.industry Neurodegeneration General Medicine Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Neurology Cerebral cortex Neurology (clinical) business Parahippocampal gyrus |
| Zdroj: | Journal of neuropathology and experimental neurology. 52(2) |
| ISSN: | 0022-3069 |
| Popis: | One of the hallmarks of Alzheimer's disease is the presence of argyrophilic plaques (arg-P) accompanying dementia and other forms of cognitive alterations. In the present investigation 195 non-demented, cognitively normal patients were grouped according to the presence or absence of critical coronary artery disease (cCAD), defined as a 75% or greater stenosis of one of the epicardial arteries. None of the subjects had significant cerebral vascular disease. The parahippocampal gyrus (PHG) and frontal pole were analyzed for the presence of arg-P, A4 deposition, ALZ-50 immunoreactive (IR) neurons and neuropil threads (NT). Individuals with cCAD have a significantly greater incidence of plaques than non-heart disease (non-HD) subjects. Every cCAD subject had ALZ-50 IR neurons in the PHG and a greater incidence of NT as compared to the non-HD subjects. Every subject with plaques also had IR neurons and NT in the PHG. Based on the presumption that early neurodegeneration labeled by ALZ-50 antibody and amyloid deposition are in some way linked, then the sequence of plaque formation is initiated by the presence of ALZ-50 IR neurons followed in order by NT, A4 deposition and diffuse form arg-P. |
| Databáze: | OpenAIRE |
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