Fatal central nervous system co-infection with SARS-CoV-2 and tuberculosis in a healthy child
| Autor: | Nidal El-Wiher, Graham Krasan, Mitual Amin, Bishara J Freij, Rabail Tariq, Ay-Ming Wang, Bassam M Gebara, Kelly Levasseur, Joseph M Fullmer, Paul M Patek, John P. Gibson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
DNA
Bacterial 0301 basic medicine medicine.medical_specialty Tuberculosis Pneumonia Viral Pediatric infections Mycobacterium tuberculosis Betacoronavirus 03 medical and health sciences Fatal Outcome 0302 clinical medicine Meningoencephalitis Biopsy Case report medicine Humans 030212 general & internal medicine Seroconversion Pandemics CNS tuberculosis biology medicine.diagnostic_test Coinfection business.industry SARS-CoV-2 lcsh:RJ1-570 COVID-19 lcsh:Pediatrics Tuberculosis Central Nervous System biology.organism_classification medicine.disease Pneumonia 030104 developmental biology Child Preschool Pediatrics Perinatology and Child Health Immunology RNA Viral Female Histopathology Coronavirus Infections business |
| Zdroj: | BMC Pediatrics BMC Pediatrics, Vol 20, Iss 1, Pp 1-7 (2020) |
| ISSN: | 1471-2431 |
| Popis: | Background Central and peripheral nervous system symptoms and complications are being increasingly recognized among individuals with pandemic SARS-CoV-2 infections, but actual detection of the virus or its RNA in the central nervous system has rarely been sought or demonstrated. Severe or fatal illnesses are attributed to SARS-CoV-2, generally without attempting to evaluate for alternative causes or co-pathogens. Case presentation A five-year-old girl with fever and headache was diagnosed with acute SARS-CoV-2-associated meningoencephalitis based on the detection of its RNA on a nasopharyngeal swab, cerebrospinal fluid analysis, and magnetic resonance imaging findings. Serial serologic tests for SARS-CoV-2 IgG and IgA showed seroconversion, consistent with an acute infection. Mental status and brain imaging findings gradually worsened despite antiviral therapy and intravenous dexamethasone. Decompressive suboccipital craniectomy for brain herniation with cerebellar biopsy on day 30 of illness, shortly before death, revealed SARS-CoV-2 RNA in cerebellar tissue using the Centers for Disease Control and Prevention 2019-nCoV Real-Time Reverse Transcriptase-PCR Diagnostic Panel. On histopathology, necrotizing granulomas with numerous acid-fast bacilli were visualized, and Mycobacterium tuberculosis complex DNA was detected by PCR. Ventricular cerebrospinal fluid that day was negative for mycobacterial DNA. Tracheal aspirate samples for mycobacterial DNA and culture from days 22 and 27 of illness were negative by PCR but grew Mycobacterium tuberculosis after 8 weeks, long after the child’s passing. She had no known exposures to tuberculosis and no chest radiographic findings to suggest it. All 6 family members had normal chest radiographs and negative interferon-γ release assay results. The source of her tuberculous infection was not identified, and further investigations by the local health department were not possible because of the State of Michigan-mandated lockdown for control of SARS-CoV-2 spread. Conclusion The detection of SARS-CoV-2 RNA in cerebellar tissue and the demonstration of seroconversion in IgG and IgA assays was consistent with acute SARS-CoV-2 infection of the central nervous infection. However, the cause of death was brain herniation from her rapidly progressive central nervous system tuberculosis. SARS-CoV-2 may mask or worsen occult tuberculous infection with severe or fatal consequences. |
| Databáze: | OpenAIRE |
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