Left atrial fibrosis predicts left ventricular ejection fraction response after atrial fibrillation ablation in heart failure patients: the Fibrosis-HF Study
| Autor: | J Piorkowski, L Pu, C. Piorkowski, A Zedda, Simon Wechselberger, Michael Wagner, Stefan Ulbrich, Ali El-Armouche, Bettina Kirstein, Thomas Schmidt, Mads Brix Kronborg, Julia Mayer, Sebastian Neudeck, T Gaspar, Anastasia Hankel, Y Huo, U Richter, Jakub Tomala |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Left ventricular ejection fraction medicine.medical_specialty medicine.medical_treatment Left atrial fibrosis Heart failure Catheter ablation Ablation Ventricular Function Left Interquartile range Fibrosis Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Sinus rhythm Heart Failure Ejection fraction business.industry Stroke Volume Atrial fibrillation medicine.disease Treatment Outcome Catheter Ablation Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Kirstein, B, Neudeck, S, Gaspar, T, Piorkowski, J, Wechselberger, S, Kronborg, M B, Zedda, A, Hankel, A, El-Armouche, A, Tomala, J, Schmidt, T, Mayer, J, Wagner, M, Ulbrich, S, Pu, L, Richter, U, Huo, Y & Piorkowski, C 2020, ' Left atrial fibrosis predicts left ventricular ejection fraction response after atrial fibrillation ablation in heart failure patients : The Fibrosis-HF Study ', Europace, vol. 22, no. 12, pp. 1812-1821 . https://doi.org/10.1093/europace/euaa179 |
| ISSN: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/euaa179 |
| Popis: | Aims Atrial fibrillation (AF) and heart failure (HF) often coexist. Catheter ablation has been reported to restore left ventricular (LV) function but patients benefit differently. This study investigated the correlation between left atrial (LA) fibrosis extent and LV ejection fraction (LVEF) recovery after AF ablation. Methods and results In this study, 103 patients [64 years, 69% men, 79% persistent AF, LVEF 33% interquartile range (IQR) (25–38)] undergoing first time AF ablation were investigated. Identification of LA fibrosis and selection of ablation strategy were based on sinus rhythm voltage mapping. Continuous rhythm monitoring was used to assess ablation success. Improvement in post-ablation LVEF was measured as primary study endpoint. An absolute increase in post-ablation LVEF ≥10% was defined as ‘Super Response’. Left atrial fibrosis was present in 38% of patients. After ablation LVEF increased by absolute 15% (IQR 6–25) (P Conclusion Presence and extent of LA fibrosis predict LVEF response in HF patients undergoing AF ablation. The assessment of LA fibrosis may impact prognostic stratification and clinical management in HF patients with AF. |
| Databáze: | OpenAIRE |
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