Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks
| Autor: | S Schifter, Rigmor Jensen, Jes Olesen, Messoud Ashina, Lars Bendtsen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Aura Calcitonin Gene-Related Peptide Migraine Disorders Radioimmunoassay Calcitonin gene-related peptide Contraceptives Oral Hormonal Central nervous system disease Internal medicine Humans Medicine Vein business.industry Vascular disease Venous blood Middle Aged medicine.disease Anesthesiology and Pain Medicine Endocrinology medicine.anatomical_structure Neurology Migraine Calcitonin Female Neurology (clinical) business |
| Zdroj: | Pain. 86:133-138 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/s0304-3959(00)00232-3 |
| Popis: | Although calcitonin gene-related peptide (CGRP) has been shown to be elevated in jugular venous blood of adult migraineurs during acute migraine attacks, it remains unknown whether CGRP is increased outside of attacks in jugular or cubital venous blood. The aim of the present study was to compare interictal plasma levels of CGRP in adult migraine patients and in healthy controls. Twenty patients with a diagnosis of migraine with or without aura and 20 healthy controls were included. In blood from the cubital vein, CGRP levels were significantly higher in patients (75+/-8 pmol/l (mean+/-SEM)) than in controls (49+/-3 pmol/l) (P=0.005). The subgroup of patients suffering exclusively from migraine without aura (n=14) also had significantly higher levels of CGRP (82+/-10 pmol/l) than controls (n=20; 49+/-3 pmol/l) (P=0.001). The findings could not be explained by confounding factors such as age, sex or use of contraceptive pills. We therefore conclude that CGRP is increased in cubital venous blood of migraineurs outside of attack. It is hypothesized that this finding may reflect a long-lasting or permanent abnormal neurogenic vascular control in patients with migraine. |
| Databáze: | OpenAIRE |
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