Revised 2017 international consensus on ANCA testing in small vessel vasculitis: support from an external quality assessment
| Autor: | Jean-Paul Tomasi, Sofie Schouwers, René-Louis Humbel, Martine Vercammen, Xavier Bossuyt, Lieve Van Hoovels, Laurence Lutteri, Sylvia Broeders, Sylvie Goletti, Carolien Bonroy |
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| Přispěvatelé: | UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Biology, Basic (bio-) Medical Sciences, Reproductive immunology and implantation |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Consensus autoantibodies Immunology Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis medicine.disease_cause urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Autoimmunity Antibodies Antineutrophil Cytoplasmic 03 medical and health sciences 0302 clinical medicine Rheumatology Proteinase 3 immune system diseases External quality assessment medicine Immunology and Allergy Humans autoimmune diseases cardiovascular diseases Fluorescent Antibody Technique Indirect skin and connective tissue diseases Anti-neutrophil cytoplasmic antibody 030203 arthritis & rheumatology Immunoassay Medicine(all) business.industry autoimmunity Autoantibody IIf medicine.disease Dermatology respiratory tract diseases 030104 developmental biology Microscopic polyangiitis Granulomatosis with polyangiitis business |
| Zdroj: | Annals of the rheumatic diseases, Vol. 78, no. 10, p. e113 (2019) |
| Popis: | We read with great interest the multicentre study of Damoiseaux et al 1–3 on the detection of antineutrophil cytoplasmic antibodies (ANCA). ANCAs are important laboratory markers to support the diagnosis of ANCA-associated small vessel vasculitis (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Traditionally, laboratories screen for ANCA by indirect immunofluorescence (IIF) and IIF positive samples are further evaluated for antibodies to proteinase 3 (PR3) or myeloperoxidase (MPO) by specific immunoassays. Such diagnostic algorithm is based on an international consensus statement on ANCA testing issued in 1999.4 Over the last two decades, the diagnostic performance of immunoassays has significantly improved. The recent multicentre study showed a … |
| Databáze: | OpenAIRE |
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