7 tesla T2*-weighted MRI as a tool to improve detection of focal cortical dysplasia
| Autor: | Jeroen Hendrikse, Eleonora Aronica, Peter H. Gosselaar, Jaco J.M. Zwanenburg, Kees P.J. Braun, Cyrille H. Ferrier, Pieter van Eijsden, Wim G.M. Spliet, Tim J. Veersema |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Drug Resistant Epilepsy medicine.medical_specialty Pathology Adolescent Preoperative care 030218 nuclear medicine & medical imaging Lesion Young Adult 03 medical and health sciences Epilepsy 0302 clinical medicine Cortex (anatomy) Preoperative Care Humans Medicine Child Retrospective Studies medicine.diagnostic_test business.industry Epileptogenic lesion Magnetic resonance imaging General Medicine Middle Aged Cortical dysplasia medicine.disease Magnetic Resonance Imaging Malformations of Cortical Development medicine.anatomical_structure Neurology Female Neurology (clinical) Radiology medicine.symptom business T2 weighted 030217 neurology & neurosurgery |
| Zdroj: | Epileptic Disorders. 18:315-323 |
| ISSN: | 1950-6945 1294-9361 |
| DOI: | 10.1684/epd.2016.0838 |
| Popis: | Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI-visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome. We describe a series of six patients with refractory epilepsy due to histopathologically-confirmed focal cortical dysplasia, for whom pre-surgical 7 tesla T2*-weighted MRI was acquired. In four of six patients, T2* sequences showed areas of marked superficial hypointensity, co-localizing with the epileptogenic lesion. 7 tesla T2* hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T2* sequences to the MRI protocol may aid in the detection of focal cortical dysplasias. |
| Databáze: | OpenAIRE |
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