Inhaled Nitric Oxide Modifies Left Ventricular Diastolic Stress in the Presence of Vasoactive Agents in Heart Failure
| Autor: | Naoyuki Hasebe, Hironobu Matsuhashi, Shunsuke Natori, Kenjiro Kikuchi, Tadashi Ihara, Yin-Tie Jin, Akira Ido, Tomoyuki Matsusaka |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pulmonary Circulation Heart disease Vasodilator Agents Drug Evaluation Preclinical Diastole Hemodynamics Procainamide Nitric Oxide Critical Care and Intensive Care Medicine Ventricular Function Left Nitroglycerin Norepinephrine Random Allocation Dogs Administration Inhalation medicine Animals Vasoconstrictor Agents Infusions Intravenous Heart Failure Inhalation business.industry Angiotensin II Isoproterenol Stroke Volume medicine.disease Pulmonary hypertension Acetylcholine Disease Models Animal Preload medicine.anatomical_structure Anesthesia Heart failure Vascular resistance Female Vascular Resistance business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 167:895-901 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200201-057oc |
| Popis: | Nitric oxide (NO) inhalation therapy has been widely used in several diseases with pulmonary hypertension. However, application of NO inhalation therapy remains controversial in heart failure. Cardiovascular effects of inhaled NO (iNO) were evaluated in dogs before and after induction of heart failure with and without infusion of vasoactive agents. iNO did not affect the baseline left ventricular (LV) function or the response to isoproterenol in control conditions or heart failure induced by procainamide. Pulmonary vascular resistance was significantly decreased by iNO in heart failure with infusion of vasoactive agents. Unexpectedly, LV end-diastolic pressure was significantly elevated by iNO in heart failure in the presence of infusion of vasoactive agents independent of their types; either the vasodilating agents of acetylcholine and nitroglycerin or the vasoconstricting agents of norepinephrine and angiotensin-II. The end-diastolic LV dimension and wall stress were also significantly increased by iNO, however, those at end systole were not affected. These results suggested that NO inhalation therapy reduced pulmonary vascular resistance, whereas in the presence of additional stress of vasoactive agents, it increased LV preload and end-diastolic wall stress in heart failure. |
| Databáze: | OpenAIRE |
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