Longitudinal effects of cognitive behavioral therapy for depression on the neural correlates of emotion regulation

Autor: Maria A. Oquendo, Harry Rubin-Falcone, Lauren Delaparte, J. John Mann, Ronit Kishon, Kevin N. Ochsner, Bruce P. Doré, Jochen Weber, Jeffrey M. Miller, Francesca Zanderigo
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_treatment
Memory
Episodic
Emotions
Neuroscience (miscellaneous)
Prefrontal Cortex
behavioral disciplines and activities
Gyrus Cinguli
Article
Lingual gyrus
03 medical and health sciences
Young Adult
0302 clinical medicine
mental disorders
medicine
Humans
Radiology
Nuclear Medicine and imaging
Longitudinal Studies
Prefrontal cortex
Depression (differential diagnoses)
Neural correlates of consciousness
Brain Mapping
medicine.diagnostic_test
Cognitive Behavioral Therapy
Autobiographical memory
Depression
medicine.disease
Magnetic Resonance Imaging
030227 psychiatry
Cognitive behavioral therapy
Psychiatry and Mental health
Treatment Outcome
Mental Recall
Major depressive disorder
Female
Psychology
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Clinical psychology
Zdroj: Psychiatry research. Neuroimaging. 271
ISSN: 1872-7506
Popis: Cognitive behavioral therapy (CBT) is effective for a substantial minority of patients suffering from major depressive disorder (MDD), but its mechanism of action at the neural level is not known. As core techniques of CBT seek to enhance emotion regulation, we scanned 31 MDD participants prior to 14 sessions of CBT using functional magnetic resonance imaging (fMRI) and a task in which participants engaged in a voluntary emotion regulation strategy while recalling negative autobiographical memories. Eighteen healthy controls were also scanned. Twenty-three MDD participants completed post-treatment fMRI scanning, and 12 healthy volunteers completed repeat scanning without intervention. Better treatment outcome was associated with longitudinal enhancement of the emotion regulation-dependent BOLD contrast within subgenual anterior cingulate, medial prefrontal cortex, and lingual gyrus. Baseline emotion regulation-dependent BOLD contrast did not predict treatment outcome or differ between MDD and control groups. CBT response may be mediated by enhanced downregulation of neural activity during emotion regulation; brain regions identified overlap with those found using a similar task in a normative sample, and include regions related to self-referential and emotion processing. Future studies should seek to determine specificity of this downregulation to CBT, and evaluate it as a treatment target in MDD.
Databáze: OpenAIRE
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