Translational neurorehabilitation research in the third world: what barriers to trial participation can teach us
| Autor: | Adriana Bastos Conforto, Annette Sterr, Leonardo G. Cohen, Sarah M. Anjos, Karina Nocelo Ferreiro de Andrade |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
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medicine.medical_specialty medicine.medical_treatment Alternative medicine Pilot Projects Article Unique identifier External validity Translational Research Biomedical Physical medicine and rehabilitation Double-Blind Method Recurrence medicine Humans Stroke Developing Countries Neurorehabilitation Aged Advanced and Specialized Nursing Protocol (science) Clinical Trials as Topic Rehabilitation business.industry Patient Selection Stroke Rehabilitation Middle Aged medicine.disease Clinical trial Physical therapy Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Brazil |
| Popis: | Background and Purpose— Most stroke rehabilitation studies have been performed in high-income countries. The aim of this study was to identify the main barriers for patient inclusion in a research protocol performed in Brazil. Methods — We evaluated reasons for exclusion of patients in a pilot, randomized, double-blinded clinical trial of stroke rehabilitation. Descriptive statistical analysis was performed. Results — Only 5.6% of 571 screened patients were included. Recurrent stroke was responsible for exclusion of 45.4% of potentially eligible patients. Conclusions — Recurrent stroke represented a big barrier to enroll patients in the protocol. External validity of rehabilitation trials will benefit from definition of study criteria according to regional characteristics of patients, including rates of recurrent stroke. Clinical Trial Registration — URL: http://www.clinicaltrials.gov . Unique identifier: NCT01333579. |
| Databáze: | OpenAIRE |
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