Active aneurysm thrombosis after Kawasaki disease in an adult: Insight into anticoagulation therapy
| Autor: | Shinji Inaba, Mie Kurata, Takumi Yasugi, Yusuke Akazawa, Hikaru Nishiyama, Takashi Higaki, Osamu Yamaguchi, Jun Aono, Tomohisa Sakaue, Mariko Eguchi, Tomozo Moritani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Surgical resection
medicine.medical_specialty business.industry Warfarin Case Report 030204 cardiovascular system & hematology medicine.disease Thrombosis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Aneurysm Internal medicine medicine Cardiology cardiovascular system Kawasaki disease 030212 general & internal medicine cardiovascular diseases Thrombus Cardiology and Cardiovascular Medicine business Pathological Artery medicine.drug |
| Zdroj: | J Cardiol Cases |
| Popis: | The management of systemic artery aneurysms secondary to Kawasaki disease (KD) in adults remains a therapeutic challenge. KD guidelines recommend the use of anticoagulation therapy with warfarin in addition to antiplatelet therapy when a giant coronary aneurysm or a history of thrombosis is documented. However, long-term use of warfarin presents several concerns. This case reports acute thrombotic occlusion due to the giant arterial aneurysm in an adult KD. A surgical resection of the aneurysm was performed because of recurrent thrombotic events, despite anticoagulant therapy with warfarin. Pathological examinations revealed a layered thrombus with inflammation in the aneurysm and Factor Xa expression mainly in newly formed thrombus. This study provides an insight into the anticoagulation therapy for cardiovascular sequelae after KD. |
| Databáze: | OpenAIRE |
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