In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family
| Autor: | Hengameh Zandi, Hossein Kazemian, Hossein A. Rahdar, Fateme Yazdani, Asieh Taji, Jalil Kardan Yamchi, Mohammad Mehdi Feizabadi, Hamid Heidari, Roya Ghanavati, Gholamreza Hamzehloo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
food.ingredient
Tuberculosis Antitubercular Agents Mycobacterium Infections Nontuberculous Drug resistance Microbial Sensitivity Tests Iran Satureja Mycobacterium tuberculosis 03 medical and health sciences food Drug Discovery Tuberculosis Multidrug-Resistant medicine Humans Pharmacology (medical) 0303 health sciences Lamiaceae Plants Medicinal biology Traditional medicine 030306 microbiology Plant Extracts Broth microdilution Nontuberculous Mycobacteria General Medicine biology.organism_classification Antimicrobial medicine.disease Infectious Diseases Mycobacterium |
| Zdroj: | Recent patents on anti-infective drug discovery. 13(3) |
| ISSN: | 2212-4071 |
| Popis: | BACKGROUND: Mycobacterium tuberculosis as an intracellular pathogen causes tuberculosis (TB). Due to the long time required for treatment, hepatotoxicity of drugs and also emergence of multidrug-resistant (MDR) and extremely drug resistant (XDR) strains, TB is currently a major public health problem. Some medicinal plants possess remarkable activity against Mycobacterium. Among them, Lamiaceae family are of pharmaceutical interest because of their potential antimicrobial properties. The aim of the study was to evaluate the in vitro activities of Satureja rechingeri, Satureja khuzestanica and Zataria multiflora against MDR M. tuberculosis and two non-tuberculous mycobacteria (NTM). The recent patents on plant compositions (US7641919 B2, US7887860 B2, US 8865231 B2, US 9345659 B2, WO 2014158797 A1 and WO 2014158877 A1) helped in selecting the anti-mycobacterial drugs. METHODS: The essential oils were prepared by the standard method. The confirmed strains were obtained from the microbial collection of Tehran University of Medical Sciences. Minimum inhibitory concentrations (MICs) of essential oils of plants against mycobacterial strains were determined using standard broth microdilution method. RESULTS: MDR M. tuberculosis was completely inhibited by Z. multiflora at 78mug/ml concentration. S. rechingeri and S. khuzestanica also showed same anti-mycobacterial activity against MDR M. tuberculosis with MICs of 156 mug/ml. The MICs of the essential oils against M. tuberculosis H37Rv, M. kansasii and M. fortuitum were in the range from 39 to 156 mug/ml. CONCLUSION: The studied medicinal plants showed notable effects against mycobacterial strains. Our results indicated that utilization of Lamiaceae family can be helpful for treatment of mycobacterial infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|