Effects of the long-term use of depot medroxyprogesterone acetate as hormonal contraceptive on bone mineral density and biochemical markers of bone remodeling
| Autor: | Mohamed Hassan, Samia Seoudi, Samira Yousef El-Mallah, Iman Abdel Mohsen, Mohamed Shaarawy |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
musculoskeletal diseases medicine.medical_specialty Deoxypyridinoline Medroxyprogesterone Population Medroxyprogesterone Acetate Bone resorption Time Bone remodeling Cohort Studies chemistry.chemical_compound Bone Density Internal medicine Contraceptive Agents Female medicine Humans Medroxyprogesterone acetate education Retrospective Studies Drug Implants Bone mineral education.field_of_study business.industry Obstetrics and Gynecology Resorption Endocrinology Reproductive Medicine chemistry Osteoporosis Female Bone Remodeling business Biomarkers medicine.drug |
| Zdroj: | Contraception. 74:297-302 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/j.contraception.2006.04.003 |
| Popis: | Purpose and Method Our objective is to evaluate the effects of the long-term use of depot medroxyprogesterone acetate (DMPA) as a method of contraception on bone mineral density (BMD) and bone remodeling. Forty women (21–44 years old) who used DMPA for contraception for 5 years, in addition to 20 age-matched healthy women (nonusers), participated in this study. Lumbar spine BMD (LS-BMD) was measured by dual-energy X-ray absorptionmetry. Serum osteocalcin (OC), a bone formation marker, was measured by enzyme amplification sorbent immunoassay. Urinary deoxypyridinoline (DPD), a bone resorption marker, was determined by enzyme immunoassay. Results Serum OC and urinary DPD levels in women who used DMPA for 5 years were significantly increased compared to the corresponding levels in nonusers. The increase of both biomarkers was more pronounced with longer duration of use. LS-BMD was significantly decreased in women on long-term DMPA use compared to LS-BMD in nonusers. The mean percentage decrease of LS-BMD in women who used DMPA for 1–2 and >5 years was 9% and 11.8%, respectively. LS-BMD was negatively correlated with serum OC and urinary DPD in women who used DMPA. On the other hand, LS-BMD and bone turnover were not significantly different between women who used DMPA for Conclusion Long-term use of DMPA (>2 years) had a significant adverse effect on BMD and induced increased bone turnover, as evidenced by a significant increase in biochemical indices of bone formation and resorption. The measurement of LS-BMD and of biomarkers of bone turnover may be recommended in women aged above 40 years and who used DMPA for a long duration (2–5 years). |
| Databáze: | OpenAIRE |
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