Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein
| Autor: | Karen J. Mackenzie, Alero Rone-Orugboh, Michael Liu, Stephen M. Anderton, Claire H. Sweenie |
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| Rok vydání: | 2006 |
| Předmět: |
T cell
Recombinant Fusion Proteins T-Lymphocytes Immunology Epitopes T-Lymphocyte medicine.disease_cause Lymphocyte Activation Epitope Myelin oligodendrocyte glycoprotein Autoimmunity Mice medicine Immune Tolerance Immunology and Allergy Animals Amino Acid Sequence Glycoproteins Antigen Presentation biology Antigen processing Immunodominant Epitopes Repertoire Experimental autoimmune encephalomyelitis hemic and immune systems medicine.disease Molecular biology Peptide Fragments Mice Inbred C57BL medicine.anatomical_structure nervous system Neurology biology.protein Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) Central tolerance Immunologic Memory Epitope Mapping |
| Zdroj: | Journal of neuroimmunology. 183(1-2) |
| ISSN: | 0165-5728 |
| Popis: | We have assessed the complexity in T cell recognition of the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 mice. Immunization with the p35-55 peptide generated two types of T cell, recognizing either a cryptic, or a naturally-processed epitope. Clear differences in the recognition of residues within a core sequence of 40-48 were observed. The majority of the p35-55-reactive repertoire in vivo appeared responsive to the intact autoantigen, supporting the notion of a failure of central tolerance to this region of MOG. Our data also provide a basis for exploring the requirements for antigen processing of MOG. |
| Databáze: | OpenAIRE |
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