Heart rate, age and the risk of progression to kidney failure in patients with CKD
| Autor: | Zoccali, C, Leonardis, D, Enia, G, Postorino, M, D'Arrigo, G, Tripepi, G, Mallamaci, F, MAURO STUDY investigators, Fatuzzo, P, Rapisarda, F |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Risk medicine.medical_specialty Sympathetic Nervous System risk factors CKD Kidney Failure Heart Rate Internal medicine Heart rate medicine Humans Renal Insufficiency Renal Insufficiency Chronic Risk factor Aged Kidney Proteinuria business.industry Proportional hazards model Hazard ratio Age Factors Absolute risk reduction Middle Aged Surgery medicine.anatomical_structure Nephrology Cohort Disease Progression Cardiology Female medicine.symptom business |
| Zdroj: | Journal of Nephrology. 25:20-27 |
| ISSN: | 1121-8428 |
| DOI: | 10.5301/jn.5000229 |
| Popis: | Background and methods: Since heart rate (HR) is a cardiovascular risk factor and a marker of sympa- thetic activity, we tested the predictive value of HR for progression to kidney failure in a well characterized cohort of 759 patients with stage 2-5 CKD followed up for 29 ± 11 months. Results: Overall, a total of 244 patients had renal events. In an unadjusted analysis by age tertiles the predictive value of HR for renal events was appar- ent only in patients in the third age tertile (older than 68 years) but not in those in the first two tertiles indi- cating effect modification by age of the HR - progres- sion to kidney failure relationship. In a multiple Cox regression model adjusting for potential confounders, a 5 beats/min increase in HR entailed a 16% risk ex- cess (Hazard Ratio = 1.16, P = .004) for renal events in patients in the third age tertile but no excess risk for the same events in patients in the first two tertiles. A statistically significant interaction (P |
| Databáze: | OpenAIRE |
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