| Autor: |
Anna-Karin Olsson, Anna Dimberg, Christer Betsholtz, Kari Alitalo, Carl-Henrik Heldin, Agneta Siegbahn, Johanna Andrae, Qi Qiao, Åsa Thulin, Maria Georganaki, Luuk van Hooren, Alessandra Vaccaro, Ragaseema Valsala Madhavan Unnithan, Zuoxiu Miao, Gabriela D'Amico, Kati Viitaniemi, Melanie Herre, Anahita Hamidi, Jessica Cedervall, Yanyu Zhang |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Table 1 and Fig 1-8 including legends. Table S1: Observed and expected numbers of Pf4-Cre;Pdgfbfl/fl embryos at different developmental stages. Figure S1: Platelet-specific PDGFB knockout embryos display no obvious abnormalities. Figure S2: Platelet counts and proportion in peripheral blood from WT and pl-PDGFB KO mice. Figure S3: Generation of RIP1-Tag2 mice lacking PDGFB in platelets. Figure S4: Lack of platelet PDGFB does not affect the angiogenic switch or tumor growth in RT2 mice. Figure S5: Tumor vessels in MC38 colon carcinoma in mice with platelet-specific PDGFB ablation have impaired function and decreased pericyte coverage. Figure S6: Increased spontaneous lung metastasis in mice with platelet-specific PDGFB ablation in the HCmel12 melanoma model. Figure S7: Reduced pericyte coverage already in pre-tumorigenic tissue in mice lacking PDGFB in platelets. Figure S8: Expression of Cxcl3, Cxcl5, Cxcl7 and Cxcl15 in tumor tissue from Pf4-Cre- and Pf4-Cre+ mice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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