Application of HPMC HME polymer as hot melt extrusion carrier in carbamazepine solid dispersion

Autor:	Xue Ke, Tianyuan Ci, Hao Wu, Yanhong Liu
Rok vydání:	2020
Předmět:	Work (thermodynamics) Materials science Polymers Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences Hypromellose Derivatives 0302 clinical medicine Drug Discovery Thermal stability Composite material Hot melt Dissolution Pharmacology chemistry.chemical_classification Drug Carriers Calorimetry Differential Scanning Organic Chemistry Hot Melt Extrusion Technology Polymer 021001 nanoscience & nanotechnology Carbamazepine chemistry Extrusion 0210 nano-technology Dispersion (chemistry)
Zdroj:	Drug Development and Industrial Pharmacy. 46:1911-1918
ISSN:	1520-5762 0363-9045
Popis:	This work is to investigate the application characteristics of a new hot melt extrusion (HME) polymer (HME-grade hydroxypropyl methylcellulose, namely HPMC HME 15LV) in solid dispersion by HME.Carbamazepine (CBZ) was chosen as the model drug. And two types of solid dispersion system was prepared by HME, that is, single carrier system which was composed of PVP VA64(VA64) or Soluplus (SOL), and binary carrier which was composed of HPMC HME 15LV and SOL. Phase analysis of the extrudates were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The dissolution, moisture absorption and thermal stability CBZ solid dispersion (CBZ-SD) were also investigated. In addition, the mechanism that affects the capsule dissolution was evaluated by the viscosity test and infiltration capability test.CBZ-SD was prepared by HME. DSC and PXRD results indicated that CBZ was amorphous in all solid dispersions. Unlike CBZ-SD powder with high dissolution, CBZ-SD capsules showed the variable gelatinization phenomenon during dissolution and different dissolution behaviors, which can be interpreted by the viscosity test and infiltration capacity test. Furthermore, compared with single carrier system, CBZ-SD made by binary carrier exhibited lower moisture absorption and better thermal stability, which is benefit to the long-term stability of CBZ-SD.HPMC HME 15LV, as a new HME carrier, has certain advantages in producing well CBZ-SD preparation. Its low viscosity can prevent the gelatinization phenomenon during capsule dissolution, as well as suitable
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0c61e9da713f99a795e1bb19f840d2 https://doi.org/10.1080/03639045.2020.1821045 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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