Morphological characteristics preceding exudative neovascularisation secondary to macular telangiectasia type 2
| Autor: | Kristina Hess, Peter Charbel Issa, Frank G Holz, Simone Tzaridis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Anastomosis Cellular and Molecular Neuroscience chemistry.chemical_compound Optical coherence tomography Ophthalmology medicine Humans Fluorescein Angiography Retrospective Studies Macular telangiectasia Retina Retinal pigment epithelium medicine.diagnostic_test business.industry Fundus photography Retinal medicine.disease Fluorescein angiography eye diseases Sensory Systems medicine.anatomical_structure chemistry Retinal Telangiectasis Macular Pigment sense organs business Tomography Optical Coherence |
| Zdroj: | British Journal of Ophthalmology. 106:1736-1741 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2020-318470 |
| Popis: | AimsTo identify morphological characteristics preceding the development of exudative neovascularisation secondary to Macular Telangiectasia type 2 (MacTel) using multimodal retinal imaging.MethodsIn this retrospective study, eyes with a minimum observation period of 6 months prior to the de novo diagnosis of an exudative neovascularisation secondary to MacTel were analysed. Morphological changes preceding the formation of neovascularisation were evaluated using colour fundus photography, infrared imaging, fluorescein angiography, macular pigment measurement and optical coherence tomography (OCT). OCT-angiography (OCT-A) images were additionally available in a subset of patients.ResultsTwenty eyes from 20 patients were examined over a median period of 17 months (range: 6–100 months). Eyes were characterised by an accelerated progression of ellipsoid zone loss (median of 0.013 mm2/month), increased thickness of the temporal parafovea and hyper-reflective lesions on OCT. The latter underwent morphological changes preceding the development of exudative neovascularisation, including an increase in size and density, and expansion to outer retinal layers and the retinal pigment epithelium. All eyes showed a foveal depletion of macular pigment. On OCT-A, a focal increase in blood flow was observed at the level of the outer retina/choriocapillaris, and retinal–retinal and retinal–choroidal anastomoses preceded the formation of exudative neovascularisation.ConclusionsMultimodal imaging allows the identification of prognostic morphological features preceding the formation of exudative neovascularisation in MacTel. Eyes exhibiting these characteristics should be monitored closely and patients should be alert for emergent symptoms in order to detect and treat neovascularisation early and, thereby, prevent irreversible visual loss. |
| Databáze: | OpenAIRE |
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